Structure of PDB 3nis Chain F

Receptor sequence
>3nisF (length=82) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GSVHKHTGRNCGRKFKIGEPLYRCHECGCDDTCVLCIHCFNPKDHVNHHV
CTDICTEFTSGICDCGDEEAWNSPLHCKAEEQ
3D structure
PDB3nis Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
ChainF
Resolution1.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F C123 C148 C151 C175 C11 C36 C39 C63
BS02 ZN F H118 C151 C177 C189 H6 C39 C65 C77
BS03 ZN F C136 C139 H157 H160 C24 C27 H45 H48
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3nis, PDBe:3nis, PDBj:3nis
PDBsum3nis
PubMed20835240
UniProtP19812|UBR1_YEAST E3 ubiquitin-protein ligase UBR1 (Gene Name=UBR1)

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