Structure of PDB 3mg8 Chain F

Receptor sequence
>3mg8F (length=237) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLVP
QKNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPA
FADRLGQYVQAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYK
GAATGKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHEDNKEKD
FELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEIN
3D structure
PDB3mg8 Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
ChainF
Resolution2.59 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T35 E51 L53 K66 G80 K167
Catalytic site (residue number reindexed from 1) T24 E40 L42 K55 G69 K156
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG F A164 R169 K173 A153 R158 K162
BS02 MG F S13 N127 S2 N116
Gene Ontology
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex

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Biological Process
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Cellular Component
External links
PDB RCSB:3mg8, PDBe:3mg8, PDBj:3mg8
PDBsum3mg8
PubMed20632995
UniProtP21242|PSA7_YEAST Probable proteasome subunit alpha type-7 (Gene Name=PRE10)

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