Structure of PDB 3lee Chain F

Receptor sequence
>3leeF (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
SSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMT
ISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAE
KYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLF
SASEFEDPLVGEDTERANSMGLFLQKTNINALHHIPDVITYLSRLRNQSV
FNFCAIPQVMAIATLAACDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSK
TRQIISTIRTQN
3D structure
PDB3lee Mechanism of Action (and Inhibition) of Head-to-Head Terpene Synthases: A Structural Investigation
ChainF
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y171 F288
Catalytic site (residue number reindexed from 1) Y134 F203
Enzyme Commision number 2.5.1.21: squalene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B65 F F54 Y73 L76 R77 D80 V179 F17 Y36 L39 R40 D43 V142
BS02 MG F D80 D84 D43 D47
Gene Ontology
Molecular Function
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0051996 squalene synthase [NAD(P)H] activity
Biological Process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0045338 farnesyl diphosphate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3lee, PDBe:3lee, PDBj:3lee
PDBsum3lee
PubMed
UniProtP37268|FDFT_HUMAN Squalene synthase (Gene Name=FDFT1)

[Back to BioLiP]