Structure of PDB 3kc3 Chain F

Receptor sequence
>3kc3F (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK
MLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDG
GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL
YTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMY
ILLCGYPPFYSNHISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLK
TEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE
3D structure
PDB3kc3 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.
ChainF
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207
Catalytic site (residue number reindexed from 1) D143 K145 E147 N148 D164
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MK2 F L70 V78 K93 E139 L141 L193 T206 D207 L27 V35 K50 E96 L98 L150 T163 D164 BindingDB: IC50=1300nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3kc3, PDBe:3kc3, PDBj:3kc3
PDBsum3kc3
PubMed19919896
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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