Structure of PDB 3jca Chain F

Receptor sequence
>3jcaF (length=253) Species: 11757 (Mouse mammary tumor virus) [Search protein sequence]
ALESAQESHALHHQNAAALRFQFHITREQAREIVKLCPNCPRGLKPRVLW
QMDVTHVSEFGKLKYVHVTVDTYSHFTFATARTGEATKDVLQHLAQSFAY
MGIPQKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYNPQGQAIVERTHQ
NIKAQLNKLQKAGKYYTPHHLLAHALFVLNHVNMDNQGHTAAERHWGPIS
ADPKPMVMWKDLLTGSWKGPDVLITAGRGYACVFPQDAESPIWVPDRFIR
PFT
3D structure
PDB3jca Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
ChainF
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F H9 H13 C37 C40 H9 H13 C37 C40
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3jca, PDBe:3jca, PDBj:3jca
PDBsum3jca
PubMed26887496
UniProtP03365|POL_MMTVB Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)

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