Structure of PDB 3hus Chain F

Receptor sequence
>3husF (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
THDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGK
DCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGS
VDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELE
DWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSD
KFFTSHKGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQG
GTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTI
3D structure
PDB3hus Impaired protofibril formation in fibrinogen gammaN308K is due to altered D:D and "A:a" interactions.
ChainF
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F D301 F322 Q329 D330 K338 C339 H340 Y363 D364 R375 D200 F221 Q228 D229 K237 C238 H239 Y262 D263 R274
BS02 CA F D318 F322 E323 D217 F221 E222
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
Biological Process
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0051258 protein polymerization
Cellular Component
GO:0005577 fibrinogen complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3hus, PDBe:3hus, PDBj:3hus
PDBsum3hus
PubMed19650644
UniProtP02679|FIBG_HUMAN Fibrinogen gamma chain (Gene Name=FGG)

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