Structure of PDB 3h4v Chain F

Receptor sequence
>3h4vF (length=270) Species: 5664 (Leishmania major) [Search protein sequence]
TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNAR
RPNSAITVQADLSNVATAPSAPVTLFTRCAELVAACYTHWGRCDVLVNNA
SSFYPTPLLRNDGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAK
HRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIR
VNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSK
AKYITGTCVKVDGGYSLTRA
3D structure
PDB3h4v Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
ChainF
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R17 D181 Y194
Catalytic site (residue number reindexed from 1) R13 D163 Y176
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP F R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 M179 V180 D181 K198 P224 L226 S227 R13 L14 H32 Y33 H34 R35 S36 L62 N99 A100 S101 S102 M161 V162 D163 K180 P206 L208 S209
BS02 DVP F S111 F113 L188 Y191 Y194 S101 F103 L170 Y173 Y176 MOAD: Ki=0.1uM
BindingDB: Ki=100nM
Gene Ontology
Molecular Function
GO:0004155 6,7-dihydropteridine reductase activity
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0031427 response to methotrexate
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3h4v, PDBe:3h4v, PDBj:3h4v
PDBsum3h4v
PubMed18245389
UniProtQ01782|PTR1_LEIMA Pteridine reductase 1 (Gene Name=PTR1)

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