Structure of PDB 3f5o Chain F

Receptor sequence
>3f5oF (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
TSMTQSLREVIKAMTKARNFERVLGKITLVSAAPGKVICEMKVEEEHTNA
IGTLHGGLTATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIV
ITAHVLKQGKTLAFTSVDLTNKATGKLIAQGRHTKHLG
3D structure
PDB3f5o The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis
ChainF
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.2.-
3.1.2.2: palmitoyl-CoA hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA F Y90 M91 S92 P93 Y89 M90 S91 P92
BS02 UOC F P80 G81 K136 P79 G80 K135
BS03 COA F V82 S83 H137 V81 S82 H136
BS04 COA F G110 K111 T112 L113 F115 G109 K110 T111 L112 F114
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047617 fatty acyl-CoA hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0051289 protein homotetramerization
GO:0120163 negative regulation of cold-induced thermogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton

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Cellular Component
External links
PDB RCSB:3f5o, PDBe:3f5o, PDBj:3f5o
PDBsum3f5o
PubMed19170545
UniProtQ9NPJ3|ACO13_HUMAN Acyl-coenzyme A thioesterase 13 (Gene Name=ACOT13)

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