Structure of PDB 3ecs Chain F

Receptor sequence
>3ecsF (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLT
SAIETLCGVDSSVAVSSGGELFLRFISKCKKIMIERGELFLRRISLSRNK
IADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLS
GKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKI
GTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKALKEEHP
WVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYLAAA
3D structure
PDB3ecs Crystal structure of the alpha subunit of human translation initiation factor 2B
ChainF
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 F S131 R132 V133 K234 S121 R122 V123 K224
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0014003 oligodendrocyte development
GO:0043434 response to peptide hormone
GO:0044237 cellular metabolic process
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3ecs, PDBe:3ecs, PDBj:3ecs
PDBsum3ecs
PubMed19631657
UniProtQ14232|EI2BA_HUMAN Translation initiation factor eIF2B subunit alpha (Gene Name=EIF2B1)

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