Structure of PDB 3coa Chain F

Receptor sequence
>3coaF (length=87) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSN
SSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNP
3D structure
PDB3coa Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification.
ChainF
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna F L183 R214 H215 S218 R225 S234 S235 W237 L29 R60 H61 S64 R71 S80 S81 W83 PDBbind-CN: Kd=128nM
BS02 dna F S164 Y165 N211 H215 G232 S10 Y11 N57 H61 G78 PDBbind-CN: Kd=128nM
BS03 CA F L217 S218 H220 F223 L63 S64 H66 F69
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3coa, PDBe:3coa, PDBj:3coa
PDBsum3coa
PubMed18786403
UniProtQ12778|FOXO1_HUMAN Forkhead box protein O1 (Gene Name=FOXO1)

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