Structure of PDB 3bf1 Chain F

Receptor sequence
>3bf1F (length=248) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
MDPMYLLVDVGNTHSVFSITEDGKTFRRWRLSTGVFQTEDELFSHLHPLL
GDAMREIKGIGVASVVPTQNTVIERFSQKYFHISPIWVKAKNGCVKWNVK
NPSEVGADRVANVVAFVKEYGKNGIIIDMGTATTVDLVVNGSYEGGAILP
GFFMMVHSLFRGTAKLPLVEVKPADFVVGKDTEENIRLGVVNGSVYALEG
IIGRIKEVYGDLPVVLTGGQSKIVKDMIKHEIFDEDLTIKGVYHFCFG
3D structure
PDB3bf1 Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
ChainF
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP F V32 F33 V35 F36
BS02 PAU F K162 T179 K165 T182 MOAD: Kd=2.7uM
BS03 ADP F T10 H11 R27 G127 T128 F150 Q217 T13 H14 R30 G130 T131 F153 Q220
BS04 PAU F E101 G103 D105 R106 T131 I145 E104 G106 D108 R109 T134 I148 MOAD: Kd=2.7uM
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0043169 cation binding
GO:0046872 metal ion binding
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3bf1, PDBe:3bf1, PDBj:3bf1
PDBsum3bf1
PubMed18186650
UniProtQ9WZY5|COAX_THEMA Type III pantothenate kinase (Gene Name=coaX)

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