Structure of PDB 2y6e Chain F

Receptor sequence
>2y6eF (length=323) Species: 9606 (Homo sapiens) [Search protein sequence]
HIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPL
GMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQ
ELLAFLLDGLHEDLNRVKKKPLKDANGRPDAVVAKEAWENHRLRNDSVIV
DTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKTVALRDCIELFTTM
ETLQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSE
FVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVS
LASEDQIVTKAAYVLFYQRRDDE
3D structure
PDB2y6e The Dusp-Ubl Domain of Usp4 Enhances its Catalytic Efficiency by Promoting Ubiquitin Exchange.
ChainF
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N306 C311 H881 D898
Catalytic site (residue number reindexed from 1) N11 C16 H278 D295
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F C461 C464 C163 C166
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2y6e, PDBe:2y6e, PDBj:2y6e
PDBsum2y6e
PubMed25404403
UniProtQ13107|UBP4_HUMAN Ubiquitin carboxyl-terminal hydrolase 4 (Gene Name=USP4)

[Back to BioLiP]