Structure of PDB 2x06 Chain F

Receptor sequence
>2x06F (length=344) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MILKPENEKKLIIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFP
QYITALKLGNINPKPDIKIVKESPATAVIDGDLGLGQVVGKKAMELAIKK
AKNVGVGVVATRNANHFGIAGYYSELAMNQDMIGITITNTEPAMAPFGGK
EKILGTNPIAIAFKGNKYKFSLDMATASIARGKILEALRKKIKIPEGCAV
DKDGKPTTDPAKALEGCILPFGGPKGYGLALAIEMLSAIGGAEVGTKVKG
TANPEERCTKGDLFIAINPEFFMGKEEFKRKVDELLDEIKNSEPAEGFEI
LIPGEIEERNKMKRKDGFEIDKNLYNQLKEICNELGLNIEDYIE
3D structure
PDB2x06 Methanoarchaeal Sulfolactate Dehydrogenase: Prototype of a New Family of Nadh-Dependent Enzymes.
ChainF
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H44
Catalytic site (residue number reindexed from 1) H44
Enzyme Commision number 1.1.1.337: L-2-hydroxycarboxylate dehydrogenase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD F P224 K225 P224 K225
BS02 NAD F F41 H44 H116 G118 I119 A120 T140 T156 D173 A175 L301 G304 I306 E307 F41 H44 H116 G118 I119 A120 T140 T156 D173 A175 L301 G304 I306 E307
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0050545 sulfopyruvate decarboxylase activity
GO:0102443 L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
Biological Process
GO:0019295 coenzyme M biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2x06, PDBe:2x06, PDBj:2x06
PDBsum2x06
PubMed15014443
UniProtQ58820|COMC_METJA L-sulfolactate dehydrogenase (Gene Name=comC)

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