Structure of PDB 2vig Chain F

Receptor sequence
>2vigF (length=374) Species: 9606 (Homo sapiens) [Search protein sequence]
LPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMD
VPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSK
EQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTK
AWITNAWEASAAVVFASTDSISAFLVPMPTPGLTLGKKEDKLGIRGSSTA
NLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDC
AVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKK
PFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITE
IYEGTSEIQRLVIAGHLLRSYRSA
3D structure
PDB2vig Crystal Structure of Human Short-Chain Acyl Coa Dehydrogenase
ChainF
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) L154 S155 G271 E392 G404
Catalytic site (residue number reindexed from 1) L121 S122 G232 E353 G365
Enzyme Commision number 1.3.8.1: short-chain acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD F R297 F300 L307 Q365 I366 G369 R258 F261 L268 Q326 I327 G330
BS02 FAD F F152 L154 S155 G160 S161 W185 T187 Y391 T394 E396 F119 L121 S122 G127 S128 W152 T154 Y352 T355 E357
BS03 COS F S161 L268 E392 G393 S128 L229 E353 G354
Gene Ontology
Molecular Function
GO:0003995 acyl-CoA dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0046359 butyrate catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005813 centrosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2vig, PDBe:2vig, PDBj:2vig
PDBsum2vig
PubMed
UniProtP16219|ACADS_HUMAN Short-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADS)

[Back to BioLiP]