Structure of PDB 2qkk Chain F

Receptor sequence
>2qkkF (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMGDFVVVYTDGCCSSNRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQ
RAEIHAACKAIEQAKTQNINKLVLYTNSMFTINGITNWVQGWKKNGWKTS
AGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQ
SE
3D structure
PDB2qkk Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
ChainF
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna F N210 M212 H260 P262 G263 R278 N77 M79 H127 P129 G130 R145
BS02 dna F N151 R179 T181 N182 Q183 F213 W221 T232 S233 V238 I239 N240 N19 R46 T48 N49 Q50 F80 W88 T99 S100 V105 I106 N107
BS03 CA F D145 N210 D274 D13 N77 D141
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2qkk, PDBe:2qkk, PDBj:2qkk
PDBsum2qkk
PubMed17964265
UniProtO60930|RNH1_HUMAN Ribonuclease H1 (Gene Name=RNASEH1)

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