Structure of PDB 2qc8 Chain F

Receptor sequence
>2qc8F (length=356) Species: 9606 (Homo sapiens) [Search protein sequence]
NKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPE
WNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPA
ETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQG
PYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPC
EGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTK
AMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNI
NDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTC
LLNETG
3D structure
PDB2qc8 Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
ChainF
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.225: protein S-acyltransferase.
6.3.1.2: glutamine synthetase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN F E136 E196 E203 E127 E187 E194
BS02 MN F E134 H253 E338 E125 H244 E329
BS03 MN F E134 E203 E125 E194
BS04 ADP F G132 E134 Q205 P208 N255 S257 R324 Y336 G123 E125 Q196 P199 N246 S248 R315 Y327
BS05 P3S F E136 E196 E203 G249 H253 R299 E305 R319 R340 E127 E187 E194 G240 H244 R290 E296 R310 R331
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004356 glutamine synthetase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016874 ligase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0006538 glutamate catabolic process
GO:0006542 glutamine biosynthetic process
GO:0008283 cell population proliferation
GO:0009267 cellular response to starvation
GO:0009749 response to glucose
GO:0010594 regulation of endothelial cell migration
GO:0018345 protein palmitoylation
GO:0042254 ribosome biogenesis
GO:1903670 regulation of sprouting angiogenesis
GO:1904749 regulation of protein localization to nucleolus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0044297 cell body
GO:0070062 extracellular exosome
GO:0097386 glial cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qc8, PDBe:2qc8, PDBj:2qc8
PDBsum2qc8
PubMed18005987
UniProtP15104|GLNA_HUMAN Glutamine synthetase (Gene Name=GLUL)

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