Structure of PDB 2p6e Chain F

Receptor sequence
>2p6eF (length=438) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DKAKKLENLLKLLQLNNDDTHKFWRTQPVKDFDEKVVEEGPIDKPKTPED
ISDKPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTK
EFFNWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVE
INFLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTC
RYTHRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKE
DIDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVE
QPDGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDP
KATKALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKFGPGD
GFLNFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML
3D structure
PDB2p6e Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
ChainF
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N169 F170 L171 T205 L455
Catalytic site (residue number reindexed from 1) N152 F153 L154 T188 L438
Enzyme Commision number 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYA F H38 F40 W41 Y103 I168 N169 F170 L171 V173 R178 S179 K180 R181 T183 I187 T191 V194 A202 Y204 I208 L210 F425 H21 F23 W24 Y86 I151 N152 F153 L154 V156 R161 S162 K163 R164 T166 I170 T174 V177 A185 Y187 I191 L193 F408
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006499 N-terminal protein myristoylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p6e, PDBe:2p6e, PDBj:2p6e
PDBsum2p6e
PubMed17513302
UniProtP14743|NMT_YEAST Glycylpeptide N-tetradecanoyltransferase (Gene Name=NMT1)

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