Structure of PDB 2oax Chain F

Receptor sequence
>2oaxF (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
PVMVLENIEPEIVYAGYDSDTAENLLSTLNRLAGKQMIQVVKWAKVLPGF
KNLPLEDQITLIQYSWMCLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQA
AFEEMRTNYIKELRKMVNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFY
TFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFH
3D structure
PDB2oax Structural basis of spirolactone recognition by the mineralocorticoid receptor
ChainF
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SNL F L769 N770 L772 A773 Q776 M807 L810 F829 C942 F956 L29 N30 L32 A33 Q36 M67 L70 F89 C198 F212 BindingDB: IC50=11nM,Ki=2.323nM
External links
PDB RCSB:2oax, PDBe:2oax, PDBj:2oax
PDBsum2oax
PubMed17569793
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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