Structure of PDB 2f7m Chain F

Receptor sequence
>2f7mF (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
VYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKY
NRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDS
SLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIE
LFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYL
PIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKI
GTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEEL
DLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIY
3D structure
PDB2f7m Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.
ChainF
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 F G56 K57 Q96 R113 G48 K49 Q88 R105
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0008299 isoprenoid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2f7m, PDBe:2f7m, PDBj:2f7m
PDBsum2f7m
PubMed16892359
UniProtP14324|FPPS_HUMAN Farnesyl pyrophosphate synthase (Gene Name=FDPS)

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