Structure of PDB 1zm4 Chain F

Receptor sequence
>1zm4F (length=207) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
EFLGDGGDVSFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQ
SIVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDARGRIRNGAL
LRVYVPRSSLPGFYRTSLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEE
GGRLETILGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALP
DYASQPG
3D structure
PDB1zm4 Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
ChainF
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E553
Catalytic site (residue number reindexed from 1) E155
Enzyme Commision number 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TAD F H440 G441 T442 A446 S449 I450 V455 R456 R458 Y470 I471 Y481 E553 H42 G43 T44 A48 S51 I52 V57 R58 R60 Y72 I73 Y83 E155
Gene Ontology
Molecular Function
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1zm4, PDBe:1zm4, PDBj:1zm4
PDBsum1zm4
PubMed16107839
UniProtP11439|TOXA_PSEAE Exotoxin A (Gene Name=eta)

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