Structure of PDB 1zbq Chain F

Receptor sequence
>1zbqF (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
SPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGS
LAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGI
LRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSA
SGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQ
TVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERT
LGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKI
DS
3D structure
PDB1zbq Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD
ChainF
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S151 Y164 K168
Catalytic site (residue number reindexed from 1) S149 Y162 K166
Enzyme Commision number 1.1.1.n12: (3R)-hydroxyacyl-CoA dehydrogenase.
4.2.1.107: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase.
4.2.1.119: enoyl-CoA hydratase 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD F G16 G20 L21 D40 L41 S75 V76 N99 A100 G101 T149 S151 Y164 K168 P194 N195 A196 S198 R199 M200 T201 G14 G18 L19 D38 L39 S73 V74 N97 A98 G99 T147 S149 Y162 K166 P192 N193 A194 S196 R197 M198 T199
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:1zbq, PDBe:1zbq, PDBj:1zbq
PDBsum1zbq
PubMed
UniProtP51659|DHB4_HUMAN Peroxisomal multifunctional enzyme type 2 (Gene Name=HSD17B4)

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