Structure of PDB 1xmn Chain F

Receptor sequence

>1xmnF (length=254) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
QFGE

3D structure

• PDB: 1xmn Crystal structure of thrombin bound to heparin
• Chain: F
• Resolution: 1.85 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H57 D102 E192 G193 D194 S195 G196
• Catalytic site (residue number reindexed from 1): H43 D99 E197 G198 D199 S200 G201
• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	F	E23 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207	E8 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N159 M206 K207 N212 R213 W214
BS02	SGN	F	K236 W237 K240	K243 W244 K247
BS03	0G6	F	H57 Y60A W60D D189 A190 C191 S195 W215 G216	H43 Y47 W50 D194 A195 C196 S200 W222 G223

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:1xmn, PDBe:1xmn, PDBj:1xmn
• PDBsum: 1xmn
• PubMed: 15548541
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)