Structure of PDB 1xbt Chain F

Receptor sequence
>1xbtF (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
RGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRALPACLL
RDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRK
PFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKY
HSVCRLCYFKK
3D structure
PDB1xbt Structures of thymidine kinase 1 of human and mycoplasmic origin
ChainF
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F C153 C156 C185 C188 C122 C125 C154 C157
BS02 TTP F M28 F29 G31 K32 S33 D58 F101 L124 T127 F128 F133 T163 V172 E173 V174 I175 G176 Y181 M11 F12 G14 K15 S16 D41 F70 L93 T96 F97 F102 T132 V141 E142 V143 I144 G145 Y150
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:1xbt, PDBe:1xbt, PDBj:1xbt
PDBsum1xbt
PubMed15611477
UniProtP04183|KITH_HUMAN Thymidine kinase, cytosolic (Gene Name=TK1)

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