Structure of PDB 1re3 Chain F

Receptor sequence
>1re3F (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
HDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKD
CQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSV
DFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELED
WNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDK
FFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGG
TYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT
3D structure
PDB1re3 BbetaGlu397 and BbetaAsp398 but not BbetaAsp432 are required for "B:b" interactions.
ChainF
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F F295 D297 D301 T305 F322 Q329 D330 K338 C339 H340 Y363 D364 F193 D195 D199 T203 F220 Q227 D228 K236 C237 H238 Y261 D262
BS02 CA F D318 D320 F322 G324 D216 D218 F220 G222
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
Biological Process
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0051258 protein polymerization
Cellular Component
GO:0005577 fibrinogen complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1re3, PDBe:1re3, PDBj:1re3
PDBsum1re3
PubMed14992584
UniProtP02679|FIBG_HUMAN Fibrinogen gamma chain (Gene Name=FGG)

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