Structure of PDB 1p9u Chain F

Receptor sequence
>1p9uF (length=300) Species: 11149 (Transmissible gastroenteritis virus) [Search protein sequence]
SGLRKMAQPSGLVEPCIVRVSYGNNVLNGLWLGDEVICPRHVIASDTTRV
INYENEMSSVRLHNFSVSKNNVFLGVVSARYKGVNLVLKVNQVNPNTPEH
KFKSIKAGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYV
LENGILYFVYMHHLELGNGSHVGSNFEGEMYGGYEDQPSMQLEGTNVMSS
DNVVAFLYAALINGERWFVTNTSMSLESYNTWAKTNSFTELSSTDAFSML
AAKTGQSVEKLLDSIVRLNKGFGGRTILSYGSLCDEFTPTEVIRQMYGVN
3D structure
PDB1p9u Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs
ChainF
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H41 G142 C144
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F H41 T47 C144 H162 L164 E165 L166 G167 D186 Q187 S189 M190 Q191 H41 T47 C144 H162 L164 E165 L166 G167 D186 Q187 S189 M190 Q191
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:1p9u, PDBe:1p9u, PDBj:1p9u
PDBsum1p9u
PubMed12746549
UniProtP0C6Y5|R1AB_CVPPU Replicase polyprotein 1ab (Gene Name=rep)

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