Structure of PDB 1o7a Chain F

Receptor sequence
>1o7aF (length=483) Species: 9606 (Homo sapiens) [Search protein sequence]
PALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHG
YIFGTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWG
ALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVK
IILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYT
PNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSKLDSFG
PINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDF
MRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI
VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLD
FGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVR
DMDDAYDRLTRHRCRMVERGIAAQPLYAGYCNH
3D structure
PDB1o7a The X-Ray Crystal Structure of Human Beta-Hexosaminidase B Provides New Insights Into Sandhoff Disease
ChainF
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D354 E355
Catalytic site (residue number reindexed from 1) D284 E285
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDL F R211 D354 E355 W405 W424 Y450 D452 W489 E491 R144 D284 E285 W335 W354 Y380 D382 W419 E421
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1o7a, PDBe:1o7a, PDBj:1o7a
PDBsum1o7a
PubMed12706724
UniProtP07686|HEXB_HUMAN Beta-hexosaminidase subunit beta (Gene Name=HEXB)

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