Structure of PDB 1np0 Chain F

Receptor sequence
>1np0F (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
LDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNP
KIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKL
APGTIVEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYK
VEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWS
SKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYCN
3D structure
PDB1np0 Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease
ChainF
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NGT F E355 W405 W424 Y450 D452 W489 E491 E40 W90 W109 Y135 D137 W174 E176 BindingDB: Ki=190nM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1np0, PDBe:1np0, PDBj:1np0
PDBsum1np0
PubMed12662933
UniProtP07686|HEXB_HUMAN Beta-hexosaminidase subunit beta (Gene Name=HEXB)

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