Structure of PDB 1fzg Chain F

Receptor sequence
>1fzgF (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
YLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIAN
KGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNW
IQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTS
TADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHN
GMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKAS
TPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT
3D structure
PDB1fzg Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
ChainF
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F D297 D301 T305 F322 Q329 K338 C339 H340 Y363 D364 D189 D193 T197 F214 Q221 K230 C231 H232 Y255 D256
BS02 CA F D318 D320 F322 G324 D210 D212 F214 G216
BS03 CA F D294 G296 D298 D301 D186 G188 D190 D193
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
Biological Process
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0051258 protein polymerization
Cellular Component
GO:0005577 fibrinogen complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1fzg, PDBe:1fzg, PDBj:1fzg
PDBsum1fzg
PubMed10074346
UniProtP02679|FIBG_HUMAN Fibrinogen gamma chain (Gene Name=FGG)

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