Structure of PDB 1d01 Chain F

Receptor sequence
>1d01F (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
AMADLEQKVLEMEASTYDGVFIWKISDFPRKRQEAVAGRIPAIFSPAFYT
SRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLM
LLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNS
YVRDDAIFIKAIVDLTGL
3D structure
PDB1d01 The structural basis for the recognition of diverse receptor sequences by TRAF2.
ChainF
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F R393 Y395 D399 G400 F410 A446 F447 R448 D450 S453 F456 A466 S467 G468 P470 R60 Y62 D66 G67 F77 A113 F114 R115 D117 S120 F123 A133 S134 G135 P137
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042981 regulation of apoptotic process
GO:0046328 regulation of JNK cascade
GO:0051865 protein autoubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:1d01, PDBe:1d01, PDBj:1d01
PDBsum1d01
PubMed10518213
UniProtQ12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Gene Name=TRAF2)

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