Structure of PDB 1cj1 Chain F

Receptor sequence
>1cj1F (length=96) Species: 9606 (Homo sapiens) [Search protein sequence]
PHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQ
HFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIE
3D structure
PDB1cj1 Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.
ChainF
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C78 F R67 R86 S88 S90 S96 Q106 H107 F108 K109 L120 W121 R11 R30 S32 S34 S40 Q50 H51 F52 K53 L64 W65
External links
PDB RCSB:1cj1, PDBe:1cj1, PDBj:1cj1
PDBsum1cj1
PubMed10395476
UniProtP62993|GRB2_HUMAN Growth factor receptor-bound protein 2 (Gene Name=GRB2)

[Back to BioLiP]