Structure of PDB 1bhx Chain F

Receptor sequence
>1bhxF (length=105) Species: 9606 (Homo sapiens) [Search protein sequence]
GQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGD
SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
DQFGE
3D structure
PDB1bhx Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.
ChainF
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R56 F D189 A190 C191 S195 S214 W215 G216 E217 D45 A46 C47 S51 S72 W73 G74 E75 MOAD: Ki=0.145uM
PDBbind-CN: -logKd/Ki=6.84,Ki=0.145uM
BindingDB: Ki=145nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1bhx, PDBe:1bhx, PDBj:1bhx
PDBsum1bhx
PubMed9733491
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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