/var/www/html/BioLiP/script/receptor1 /var/www/html/BioLiP/output/7yl0F.pdb.gz -
ATOM 1 N LYS R 1 198.719 139.614 144.169 1.00186.14 N
ATOM 2 CA LYS R 1 197.656 140.221 143.379 1.00186.14 C
ATOM 3 C LYS R 1 197.393 141.656 143.813 1.00186.14 C
ATOM 4 O LYS R 1 198.013 142.572 143.303 1.00186.14 O
ATOM 5 CB LYS R 1 196.377 139.393 143.471 1.00186.14 C
ATOM 6 CG LYS R 1 196.490 138.031 142.811 1.00186.14 C
ATOM 7 CD LYS R 1 195.142 137.340 142.711 1.00186.14 C
ATOM 8 CE LYS R 1 195.249 136.056 141.908 1.00186.14 C
ATOM 9 NZ LYS R 1 193.944 135.347 141.806 1.00186.14 N
ATOM 10 N CYS R 2 196.480 141.828 144.757 1.00190.10 N
ATOM 11 CA CYS R 2 196.108 143.162 145.194 1.00190.10 C
ATOM 12 C CYS R 2 196.935 143.589 146.421 1.00190.10 C
ATOM 13 O CYS R 2 196.384 143.730 147.512 1.00190.10 O
ATOM 14 CB CYS R 2 194.580 143.172 145.438 1.00190.10 C
ATOM 15 SG CYS R 2 193.610 142.110 144.284 1.00190.10 S
ATOM 16 N ASN R 3 198.249 143.800 146.253 1.00192.23 N
ATOM 17 CA ASN R 3 199.109 144.160 147.353 1.00192.23 C
ATOM 18 C ASN R 3 198.723 145.490 147.932 1.00192.23 C
ATOM 19 O ASN R 3 198.674 145.589 149.129 1.00192.23 O
ATOM 20 CB ASN R 3 200.567 144.222 146.896 1.00192.23 C
ATOM 21 CG ASN R 3 201.152 142.854 146.599 1.00192.23 C
ATOM 22 OD1 ASN R 3 200.681 141.833 147.098 1.00192.23 O
ATOM 23 ND2 ASN R 3 202.190 142.830 145.774 1.00192.23 N
ATOM 24 N THR R 4 198.383 146.488 147.113 1.00191.05 N
ATOM 25 CA THR R 4 198.151 147.842 147.627 1.00191.05 C
ATOM 26 C THR R 4 196.753 148.274 148.091 1.00191.05 C
ATOM 27 O THR R 4 196.583 148.532 149.284 1.00191.05 O
ATOM 28 CB THR R 4 198.665 148.892 146.626 1.00 30.00 C
ATOM 29 OG1 THR R 4 200.077 148.723 146.433 1.00 30.00 O
ATOM 30 CG2 THR R 4 198.394 150.300 147.135 1.00 30.00 C
ATOM 31 N ALA R 5 195.751 148.329 147.211 1.00184.18 N
ATOM 32 CA ALA R 5 194.448 148.846 147.675 1.00184.18 C
ATOM 33 C ALA R 5 193.143 148.501 146.974 1.00184.18 C
ATOM 34 O ALA R 5 193.148 148.195 145.783 1.00184.18 O
ATOM 35 CB ALA R 5 194.532 150.363 147.807 1.00184.18 C
ATOM 36 N THR R 6 192.041 148.497 147.722 1.00176.83 N
ATOM 37 CA THR R 6 190.692 148.351 147.156 1.00176.83 C
ATOM 38 C THR R 6 190.397 147.224 146.162 1.00176.83 C
ATOM 39 O THR R 6 189.824 147.481 145.103 1.00176.83 O
ATOM 40 CB THR R 6 190.221 149.681 146.527 1.00176.83 C
ATOM 41 OG1 THR R 6 190.530 150.766 147.410 1.00176.83 O
ATOM 42 CG2 THR R 6 188.719 149.652 146.274 1.00176.83 C
ATOM 43 N CYS R 7 190.723 145.995 146.500 1.00173.53 N
ATOM 44 CA CYS R 7 190.494 144.944 145.539 1.00173.53 C
ATOM 45 C CYS R 7 189.447 143.970 146.031 1.00173.53 C
ATOM 46 O CYS R 7 189.659 143.266 147.018 1.00173.53 O
ATOM 47 CB CYS R 7 191.793 144.224 145.283 1.00173.53 C
ATOM 48 SG CYS R 7 191.635 142.685 144.372 1.00173.53 S
ATOM 49 N ALA R 8 188.310 143.927 145.347 1.00151.59 N
ATOM 50 CA ALA R 8 187.244 143.057 145.812 1.00151.59 C
ATOM 51 C ALA R 8 187.041 141.901 144.855 1.00151.59 C
ATOM 52 O ALA R 8 187.212 142.071 143.648 1.00151.59 O
ATOM 53 CB ALA R 8 185.961 143.844 145.950 1.00151.59 C
ATOM 54 N THR R 9 186.681 140.737 145.379 1.00140.87 N
ATOM 55 CA THR R 9 186.494 139.555 144.548 1.00140.87 C
ATOM 56 C THR R 9 185.373 138.681 145.020 1.00140.87 C
ATOM 57 O THR R 9 185.360 138.262 146.171 1.00140.87 O
ATOM 58 CB THR R 9 187.747 138.664 144.567 1.00140.87 C
ATOM 59 OG1 THR R 9 188.862 139.402 144.047 1.00140.87 O
ATOM 60 CG2 THR R 9 187.540 137.413 143.730 1.00140.87 C
ATOM 61 N GLN R 10 184.428 138.385 144.145 1.00127.98 N
ATOM 62 CA GLN R 10 183.389 137.443 144.511 1.00127.98 C
ATOM 63 C GLN R 10 183.688 136.209 143.692 1.00127.98 C
ATOM 64 O GLN R 10 183.808 136.283 142.472 1.00127.98 O
ATOM 65 CB GLN R 10 182.002 137.982 144.175 1.00127.98 C
ATOM 66 CG GLN R 10 180.872 137.005 144.439 1.00127.98 C
ATOM 67 CD GLN R 10 179.519 137.682 144.449 1.00127.98 C
ATOM 68 OE1 GLN R 10 179.427 138.904 144.562 1.00127.98 O
ATOM 69 NE2 GLN R 10 178.459 136.892 144.338 1.00127.98 N
ATOM 70 N ARG R 11 183.819 135.071 144.357 1.00126.76 N
ATOM 71 CA ARG R 11 184.150 133.832 143.678 1.00126.76 C
ATOM 72 C ARG R 11 182.961 132.900 143.803 1.00126.76 C
ATOM 73 O ARG R 11 182.608 132.520 144.908 1.00126.76 O
ATOM 74 CB ARG R 11 185.372 133.252 144.371 1.00126.76 C
ATOM 75 CG ARG R 11 185.905 131.940 143.829 1.00126.76 C
ATOM 76 CD ARG R 11 187.114 131.533 144.656 1.00126.76 C
ATOM 77 NE ARG R 11 187.615 130.202 144.325 1.00126.76 N
ATOM 78 CZ ARG R 11 188.653 129.633 144.931 1.00126.76 C
ATOM 79 NH1 ARG R 11 189.293 130.280 145.895 1.00126.76 N
ATOM 80 NH2 ARG R 11 189.050 128.419 144.577 1.00126.76 N
ATOM 81 N LEU R 12 182.304 132.610 142.692 1.00115.44 N
ATOM 82 CA LEU R 12 181.173 131.720 142.772 1.00115.44 C
ATOM 83 C LEU R 12 181.328 130.519 141.865 1.00115.44 C
ATOM 84 O LEU R 12 181.446 130.650 140.646 1.00115.44 O
ATOM 85 CB LEU R 12 179.880 132.469 142.434 1.00115.44 C
ATOM 86 CG LEU R 12 178.568 131.703 142.616 1.00115.44 C
ATOM 87 CD1 LEU R 12 177.376 132.632 142.443 1.00115.44 C
ATOM 88 CD2 LEU R 12 178.481 130.528 141.654 1.00115.44 C
ATOM 89 N ALA R 13 181.325 129.345 142.476 1.00114.35 N
ATOM 90 CA ALA R 13 181.356 128.099 141.718 1.00114.35 C
ATOM 91 C ALA R 13 180.075 127.340 142.006 1.00114.35 C
ATOM 92 O ALA R 13 179.878 126.847 143.122 1.00114.35 O
ATOM 93 CB ALA R 13 182.580 127.260 142.094 1.00114.35 C
ATOM 94 N ASN R 14 179.204 127.263 141.001 1.00113.22 N
ATOM 95 CA ASN R 14 177.932 126.576 141.164 1.00113.22 C
ATOM 96 C ASN R 14 177.852 125.357 140.280 1.00113.22 C
ATOM 97 O ASN R 14 178.063 125.451 139.081 1.00113.22 O
ATOM 98 CB ASN R 14 176.769 127.519 140.878 1.00113.22 C
ATOM 99 CG ASN R 14 175.420 126.901 141.180 1.00113.22 C
ATOM 100 OD1 ASN R 14 174.419 127.244 140.555 1.00113.22 O
ATOM 101 ND2 ASN R 14 175.386 125.989 142.139 1.00113.22 N
ATOM 102 N PHE R 15 177.569 124.211 140.863 1.00111.78 N
ATOM 103 CA PHE R 15 177.441 122.950 140.146 1.00111.78 C
ATOM 104 C PHE R 15 176.118 122.317 140.532 1.00111.78 C
ATOM 105 O PHE R 15 175.846 122.119 141.719 1.00111.78 O
ATOM 106 CB PHE R 15 178.597 121.997 140.473 1.00111.78 C
ATOM 107 CG PHE R 15 179.956 122.635 140.411 1.00111.78 C
ATOM 108 CD1 PHE R 15 180.432 123.394 141.468 1.00111.78 C
ATOM 109 CD2 PHE R 15 180.777 122.450 139.311 1.00111.78 C
ATOM 110 CE1 PHE R 15 181.684 123.975 141.417 1.00111.78 C
ATOM 111 CE2 PHE R 15 182.035 123.027 139.261 1.00111.78 C
ATOM 112 CZ PHE R 15 182.486 123.791 140.314 1.00111.78 C
ATOM 113 N LEU R 16 175.307 122.001 139.529 1.00 96.46 N
ATOM 114 CA LEU R 16 173.999 121.405 139.760 1.00 96.46 C
ATOM 115 C LEU R 16 173.916 120.128 138.941 1.00 96.46 C
ATOM 116 O LEU R 16 174.283 120.128 137.772 1.00 96.46 O
ATOM 117 CB LEU R 16 172.925 122.379 139.292 1.00 96.46 C
ATOM 118 CG LEU R 16 171.489 122.256 139.789 1.00 96.46 C
ATOM 119 CD1 LEU R 16 170.862 123.639 139.737 1.00 96.46 C
ATOM 120 CD2 LEU R 16 170.698 121.289 138.923 1.00 96.46 C
ATOM 121 N VAL R 17 173.443 119.044 139.545 1.00 93.92 N
ATOM 122 CA VAL R 17 173.318 117.775 138.844 1.00 93.92 C
ATOM 123 C VAL R 17 171.933 117.207 139.051 1.00 93.92 C
ATOM 124 O VAL R 17 171.681 116.576 140.057 1.00 93.92 O
ATOM 125 CB VAL R 17 174.305 116.749 139.407 1.00 93.92 C
ATOM 126 CG1 VAL R 17 174.259 115.451 138.609 1.00 93.92 C
ATOM 127 CG2 VAL R 17 175.719 117.302 139.451 1.00 93.92 C
ATOM 128 N HIS R 18 171.029 117.414 138.111 1.00 93.10 N
ATOM 129 CA HIS R 18 169.715 116.831 138.231 1.00 93.10 C
ATOM 130 C HIS R 18 169.738 115.598 137.400 1.00 93.10 C
ATOM 131 O HIS R 18 169.984 115.659 136.212 1.00 93.10 O
ATOM 132 CB HIS R 18 168.656 117.776 137.686 1.00 93.10 C
ATOM 133 CG HIS R 18 167.269 117.212 137.690 1.00 93.10 C
ATOM 134 ND1 HIS R 18 166.320 117.582 138.614 1.00 93.10 N
ATOM 135 CD2 HIS R 18 166.666 116.317 136.869 1.00 93.10 C
ATOM 136 CE1 HIS R 18 165.196 116.937 138.371 1.00 93.10 C
ATOM 137 NE2 HIS R 18 165.378 116.161 137.319 1.00 93.10 N
ATOM 138 N SER R 19 169.475 114.460 138.002 1.00 95.21 N
ATOM 139 CA SER R 19 169.438 113.234 137.253 1.00 95.21 C
ATOM 140 C SER R 19 168.222 112.453 137.619 1.00 95.21 C
ATOM 141 O SER R 19 167.968 112.229 138.787 1.00 95.21 O
ATOM 142 CB SER R 19 170.666 112.400 137.549 1.00 95.21 C
ATOM 143 OG SER R 19 170.546 111.116 136.969 1.00 95.21 O
ATOM 144 N SER R 20 167.453 112.029 136.634 1.00 97.57 N
ATOM 145 CA SER R 20 166.330 111.182 136.942 1.00 97.57 C
ATOM 146 C SER R 20 166.493 109.922 136.159 1.00 97.57 C
ATOM 147 O SER R 20 166.520 109.962 134.945 1.00 97.57 O
ATOM 148 CB SER R 20 165.027 111.851 136.543 1.00 97.57 C
ATOM 149 OG SER R 20 163.957 110.927 136.580 1.00 97.57 O
ATOM 150 N ASN R 21 166.629 108.782 136.815 1.00 97.79 N
ATOM 151 CA ASN R 21 166.681 107.519 136.103 1.00 97.79 C
ATOM 152 C ASN R 21 165.395 106.840 136.447 1.00 97.79 C
ATOM 153 O ASN R 21 165.235 106.374 137.562 1.00 97.79 O
ATOM 154 CB ASN R 21 167.862 106.680 136.551 1.00 97.79 C
ATOM 155 CG ASN R 21 169.192 107.344 136.269 1.00 97.79 C
ATOM 156 OD1 ASN R 21 170.196 107.024 136.900 1.00 97.79 O
ATOM 157 ND2 ASN R 21 169.210 108.271 135.320 1.00 97.79 N
ATOM 158 N ASN R 22 164.459 106.813 135.521 1.00 96.40 N
ATOM 159 CA ASN R 22 163.158 106.246 135.805 1.00 96.40 C
ATOM 160 C ASN R 22 163.047 104.857 135.234 1.00 96.40 C
ATOM 161 O ASN R 22 162.673 104.694 134.083 1.00 96.40 O
ATOM 162 CB ASN R 22 162.094 107.166 135.225 1.00 96.40 C
ATOM 163 CG ASN R 22 160.731 106.529 135.145 1.00 96.40 C
ATOM 164 OD1 ASN R 22 160.026 106.696 134.160 1.00 96.40 O
ATOM 165 ND2 ASN R 22 160.366 105.785 136.158 1.00 96.40 N
ATOM 166 N PHE R 23 163.392 103.835 136.003 1.00100.58 N
ATOM 167 CA PHE R 23 163.179 102.497 135.471 1.00100.58 C
ATOM 168 C PHE R 23 161.783 102.062 135.827 1.00100.58 C
ATOM 169 O PHE R 23 161.623 101.049 136.491 1.00100.58 O
ATOM 170 CB PHE R 23 164.122 101.487 136.113 1.00100.58 C
ATOM 171 CG PHE R 23 165.573 101.722 135.838 1.00100.58 C
ATOM 172 CD1 PHE R 23 166.266 102.726 136.488 1.00100.58 C
ATOM 173 CD2 PHE R 23 166.260 100.900 134.971 1.00100.58 C
ATOM 174 CE1 PHE R 23 167.607 102.933 136.246 1.00100.58 C
ATOM 175 CE2 PHE R 23 167.604 101.093 134.726 1.00100.58 C
ATOM 176 CZ PHE R 23 168.279 102.113 135.363 1.00100.58 C
ATOM 177 N GLY R 24 160.765 102.776 135.388 1.00101.55 N
ATOM 178 CA GLY R 24 159.424 102.438 135.820 1.00101.55 C
ATOM 179 C GLY R 24 158.407 103.431 135.333 1.00101.55 C
ATOM 180 O GLY R 24 158.672 104.180 134.406 1.00101.55 O
ATOM 181 N ALA R 25 157.244 103.467 135.964 1.00 99.93 N
ATOM 182 CA ALA R 25 156.185 104.340 135.487 1.00 99.93 C
ATOM 183 C ALA R 25 155.999 105.590 136.300 1.00 99.93 C
ATOM 184 O ALA R 25 155.807 105.524 137.498 1.00 99.93 O
ATOM 185 CB ALA R 25 154.883 103.574 135.435 1.00 99.93 C
ATOM 186 N ILE R 26 156.055 106.744 135.646 1.00 94.15 N
ATOM 187 CA ILE R 26 155.804 108.011 136.312 1.00 94.15 C
ATOM 188 C ILE R 26 154.589 108.541 135.607 1.00 94.15 C
ATOM 189 O ILE R 26 154.562 108.580 134.392 1.00 94.15 O
ATOM 190 CB ILE R 26 156.908 109.040 136.050 1.00 94.15 C
ATOM 191 CG1 ILE R 26 158.257 108.557 136.555 1.00 94.15 C
ATOM 192 CG2 ILE R 26 156.567 110.381 136.682 1.00 94.15 C
ATOM 193 CD1 ILE R 26 159.324 109.622 136.479 1.00 94.15 C
ATOM 194 N LEU R 27 153.571 108.942 136.338 1.00 96.67 N
ATOM 195 CA LEU R 27 152.419 109.539 135.708 1.00 96.67 C
ATOM 196 C LEU R 27 152.221 110.874 136.360 1.00 96.67 C
ATOM 197 O LEU R 27 152.248 110.976 137.574 1.00 96.67 O
ATOM 198 CB LEU R 27 151.198 108.652 135.912 1.00 96.67 C
ATOM 199 CG LEU R 27 149.848 108.957 135.257 1.00 96.67 C
ATOM 200 CD1 LEU R 27 149.067 107.665 135.076 1.00 96.67 C
ATOM 201 CD2 LEU R 27 149.019 109.973 136.028 1.00 96.67 C
ATOM 202 N SER R 28 151.981 111.905 135.567 1.00 94.85 N
ATOM 203 CA SER R 28 151.801 113.233 136.113 1.00 94.85 C
ATOM 204 C SER R 28 150.746 114.021 135.393 1.00 94.85 C
ATOM 205 O SER R 28 150.673 113.984 134.180 1.00 94.85 O
ATOM 206 CB SER R 28 153.107 114.004 136.053 1.00 94.85 C
ATOM 207 OG SER R 28 152.899 115.359 136.396 1.00 94.85 O
ATOM 208 N SER R 29 149.927 114.753 136.126 1.00 93.36 N
ATOM 209 CA SER R 29 148.920 115.586 135.498 1.00 93.36 C
ATOM 210 C SER R 29 148.927 116.953 136.119 1.00 93.36 C
ATOM 211 O SER R 29 148.813 117.075 137.322 1.00 93.36 O
ATOM 212 CB SER R 29 147.542 114.972 135.661 1.00 93.36 C
ATOM 213 OG SER R 29 146.541 115.879 135.241 1.00 93.36 O
ATOM 214 N THR R 30 149.051 117.992 135.311 1.00 87.13 N
ATOM 215 CA THR R 30 148.982 119.333 135.850 1.00 87.13 C
ATOM 216 C THR R 30 147.802 119.994 135.196 1.00 87.13 C
ATOM 217 O THR R 30 147.794 120.162 133.994 1.00 87.13 O
ATOM 218 CB THR R 30 150.246 120.123 135.517 1.00 87.13 C
ATOM 219 OG1 THR R 30 151.397 119.355 135.885 1.00 87.13 O
ATOM 220 CG2 THR R 30 150.264 121.442 136.264 1.00 87.13 C
ATOM 221 N ASN R 31 146.781 120.352 135.955 1.00 82.15 N
ATOM 222 CA ASN R 31 145.599 120.937 135.366 1.00 82.15 C
ATOM 223 C ASN R 31 145.412 122.331 135.908 1.00 82.15 C
ATOM 224 O ASN R 31 144.665 122.527 136.848 1.00 82.15 O
ATOM 225 CB ASN R 31 144.351 120.121 135.671 1.00 82.15 C
ATOM 226 CG ASN R 31 144.389 118.726 135.088 1.00 82.15 C
ATOM 227 OD1 ASN R 31 143.609 117.866 135.489 1.00 82.15 O
ATOM 228 ND2 ASN R 31 145.283 118.492 134.141 1.00 82.15 N
ATOM 229 N VAL R 32 146.065 123.314 135.310 1.00 77.91 N
ATOM 230 CA VAL R 32 145.970 124.661 135.836 1.00 77.91 C
ATOM 231 C VAL R 32 144.897 125.468 135.139 1.00 77.91 C
ATOM 232 O VAL R 32 145.004 125.751 133.963 1.00 77.91 O
ATOM 233 CB VAL R 32 147.254 125.423 135.590 1.00 77.91 C
ATOM 234 CG1 VAL R 32 147.056 126.878 135.972 1.00 77.91 C
ATOM 235 CG2 VAL R 32 148.407 124.780 136.338 1.00 77.91 C
ATOM 236 N GLY R 33 143.867 125.868 135.879 1.00 75.92 N
ATOM 237 CA GLY R 33 142.803 126.675 135.304 1.00 75.92 C
ATOM 238 C GLY R 33 141.831 125.842 134.503 1.00 75.92 C
ATOM 239 O GLY R 33 140.828 126.356 134.005 1.00 75.92 O
ATOM 240 N SER R 34 142.116 124.552 134.374 1.00 76.59 N
ATOM 241 CA SER R 34 141.253 123.677 133.635 1.00 76.59 C
ATOM 242 C SER R 34 140.006 123.421 134.397 1.00 76.59 C
ATOM 243 O SER R 34 139.978 123.631 135.560 1.00 76.59 O
ATOM 244 CB SER R 34 141.965 122.367 133.396 1.00 76.59 C
ATOM 245 OG SER R 34 141.108 121.434 132.768 1.00 76.59 O
ATOM 246 N ASN R 35 138.935 123.023 133.756 1.00 79.18 N
ATOM 247 CA ASN R 35 137.757 122.657 134.500 1.00 79.18 C
ATOM 248 C ASN R 35 137.136 121.485 133.818 1.00 79.18 C
ATOM 249 O ASN R 35 137.282 121.332 132.633 1.00 79.18 O
ATOM 250 CB ASN R 35 136.764 123.802 134.549 1.00 79.18 C
ATOM 251 CG ASN R 35 137.336 125.047 135.180 1.00 79.18 C
ATOM 252 OD1 ASN R 35 137.577 126.047 134.516 1.00 79.18 O
ATOM 253 ND2 ASN R 35 137.580 124.985 136.467 1.00 79.18 N
ATOM 254 N THR R 36 136.446 120.638 134.546 1.00 87.70 N
ATOM 255 CA THR R 36 135.748 119.546 133.916 1.00 87.70 C
ATOM 256 C THR R 36 134.299 119.676 134.266 1.00 87.70 C
ATOM 257 O THR R 36 133.961 119.785 135.430 1.00 87.70 O
ATOM 258 CB THR R 36 136.258 118.201 134.416 1.00 87.70 C
ATOM 259 OG1 THR R 36 137.682 118.152 134.281 1.00 87.70 O
ATOM 260 CG2 THR R 36 135.640 117.065 133.627 1.00 87.70 C
ATOM 261 N TYR R 37 133.259 119.886 133.688 1.00 20.00 N
ATOM 262 CA TYR R 37 131.791 119.944 133.695 1.00 20.00 C
ATOM 263 C TYR R 37 131.234 118.587 133.349 1.00 20.00 C
ATOM 264 O TYR R 37 131.856 117.844 132.621 1.00 20.00 O
ATOM 265 CB TYR R 37 131.316 120.970 132.668 1.00 20.00 C
ATOM 266 CG TYR R 37 131.745 122.348 133.097 1.00 20.00 C
ATOM 267 CD1 TYR R 37 133.045 122.766 132.875 1.00 20.00 C
ATOM 268 CD2 TYR R 37 130.839 123.196 133.706 1.00 20.00 C
ATOM 269 CE1 TYR R 37 133.441 124.030 133.269 1.00 20.00 C
ATOM 270 CE2 TYR R 37 131.231 124.457 134.104 1.00 20.00 C
ATOM 271 OH TYR R 37 132.923 126.124 134.273 1.00 20.00 O
ATOM 272 CZ TYR R 37 132.535 124.879 133.884 1.00 20.00 C
ATOM 273 NXT TYR R 37 130.042 118.202 133.848 1.00 20.00 N
TER