Structure of PDB 8hfr Chain EX

Receptor sequence
>8hfrEX (length=347) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SDTISFLRGVLLKRYDPQTKLLNLGALHSDPELIQKGVQSKMFPAMMKLA
STEKSLIVESVNLADNQLKDISAISTLAQTFPNLKNLCLANNQIFRFRSL
EVWKNKFKDLRELLMTNNPITTDKLYRTEMLRLFPKLVVLDNVIVRDEQK
LQTVYSLPMKIQQFFFENDALGQSSTDFATNFLNLWDNNREQLLNLYSPQ
SQFSVSVDSTIPPSTVTDSDQTPAFGYYMSSSRNISKVSSEKSIQQRLSI
GQESINSIFKTLPKTKHHLQEQPNEYSMETISYPQINGFVITLHGFFEET
GKPELENNKLSKKSFDRTWVIVPMNNSVIIASDLLTVRAYSTGAWKT
3D structure
PDB8hfr Nuclear export of pre-60S particles through the nuclear pore complex.
ChainEX
Resolution2.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna EX G332 E412 N438 G226 E306 N308
BS02 rna EX S345 S346 S239 S240
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0015288 porin activity
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0008033 tRNA processing
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0051028 mRNA transport
GO:0055085 transmembrane transport
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0042272 nuclear RNA export factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hfr, PDBe:8hfr, PDBj:8hfr
PDBsum8hfr
PubMed37258668
UniProtQ99257|MEX67_YEAST mRNA export factor MEX67 (Gene Name=MEX67)

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