Structure of PDB 6tu7 Chain EP1

Receptor sequence
>6tu7EP1 (length=372) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
DVQALVVDNGSGNVKAGVAGDDAPRSVFPSIVGRPKNPGIMVGMEEKDAF
VGDEAQTKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRAAPEEHPV
LLTEAPLNPKGNRERMTQIMFESFNVPAMYVAIQAVLSLYSSGRTTGIVL
DSGDGVSHTVPIYEGYALPHAIMRLDLAGRDLTEYLMKILHERGYGFSTS
AEKEIVRDIKEKLCYIALNFDEEMKTSEQSSDIEKSYELPDGNIITVGNE
RFRCPEALFQPSFLGKEAAGIHTTTFNSIKKCDVDIRKDLYGNIVLSGGT
TMYEGIGERLTRDITTLAPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQ
QMWITKEEYDESGPSIVHRKCF
3D structure
PDB6tu7 High-resolution structures of malaria parasite actomyosin and actin filaments.
ChainEP1
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP EP1 G14 G16 G157 D158 K214 G303 Y307 K337 G10 G12 G153 D154 K210 G299 Y303 K333
BS02 9UE EP1 G198 Y199 G200 E206 L243 G194 Y195 G196 E202 L239
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0007010 cytoskeleton organization
GO:0009665 plastid inheritance
GO:0020014 schizogony
GO:0070360 symbiont-mediated actin polymerization-dependent cell-to-cell migration in host
GO:0085017 entry into host cell by a symbiont-containing vacuole
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0015629 actin cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tu7, PDBe:6tu7, PDBj:6tu7
PDBsum6tu7
PubMed35377914
UniProtQ8I4X0|ACT1_PLAF7 Actin-1 (Gene Name=ACT1)

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