Structure of PDB 7aju Chain EN

Receptor sequence
>7ajuEN (length=963) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
LADSFEQEASREVDASKGLTNSETLQVEQDGKVRLSHQVRHQVALPPNYD
YTPIAEHKRVNEARTYPFTLDPFQDTAISCIDRGESVLVSAHTSAGKTVV
AEYAIAQSLKNKQRVIYTSPIKALSNQKYRELLAEFGDVGLMTGDITINP
DAGCLVMTTEILRSMLYRGSEVMREVAWVIFDEVHYMRDKERGVVWEETI
ILLPDKVRYVFLSATIPNAMEFAEWICKIHSQPCHIVYTNFRPTPLQHYL
FPAHGDGIYLVVDEKSTFREENFQKAMASISGDIYKIVKMIWKKKYNPVI
VFSFSKRDCEELALKMSKLDFNSDDEKEALTKIFNNAIALLPETDRELPQ
IKHILPLLRRGIGIHHSGLLPILKEVIEILFQEGFLKVLFATETFSIGLN
MPAKTVVFTSVRKWDGQQFRWVSGGEYIQMSGRAGRRGLDDRGIVIMMID
EKMEPQVAKGMVKGQADRLDSAFHLGYNMILNLMRVEGISPEFMLEHSFF
QFQNVISVPVMEKKLAELKKDFDGIEVEDEENVKEYHEIEQAIKGYREDV
RQVVTHPANALSFLQPGRLVEISVNGKDNYGWGAVVDFAKRINKRNPSAV
YTDHESYIVNVVVNTMYIDSPVNLLKPFNPTLPEGIRPAEEGEKSICAVI
PITLDSIKSIGNLRLYMPKDIRASGQKETVGKSLREVNRRFPDGIPVLDP
VKNMKIEDEDFLKLMKKIDVLNTKLSSNPLTNSMRLEELYGKYSRKHDLH
EDMKQLKRKISESQAVIQLDDLRRRKRVLRRLGFCTPNDIIELKGRVACE
ISSGDELLLTELIFNGNFNELKPEQAAALLSCFAFQERCKEAPRLKPELA
EPLKAMREIAAKIAKIMKDSKIEVVEKDYVESFRHELMEVVYEWCRGATF
TQICKMTDVYEGSLIRMFKRLEELVKELVDVANTIGNSSLKEKMEAVLKL
IHRDIVSAGSLYL
3D structure
PDB7aju Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
ChainEN
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna EN G224 H476 S477 W524 G526 S913 G144 H366 S367 W414 G416 S803
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0003824 catalytic activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008143 poly(A) binding
GO:0016491 oxidoreductase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0034458 3'-5' RNA helicase activity
Biological Process
GO:0000292 RNA fragment catabolic process
GO:0000460 maturation of 5.8S rRNA
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0016075 rRNA catabolic process
GO:0034475 U4 snRNA 3'-end processing
GO:0034476 U5 snRNA 3'-end processing
GO:0071028 nuclear mRNA surveillance
GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 TRAMP-dependent tRNA surveillance pathway
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process
GO:0071051 poly(A)-dependent snoRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0031499 TRAMP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7aju, PDBe:7aju, PDBj:7aju
PDBsum7aju
PubMed33326748
UniProtP47047|MTR4_YEAST ATP-dependent RNA helicase DOB1 (Gene Name=MTR4)

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