Structure of PDB 7zx0 Chain EEE

Receptor sequence
>7zx0EEE (length=632) Species: 9606 (Homo sapiens) [Search protein sequence]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIIRDDGFPIKGCDDT
LVVGLAVCWGGRDAYYFSLQKEQPPSLDPSLTLKDRMWYLQSCLRKESDK
ECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSI
VTSFLPHELPLLEGMETSSLGLNAGSEHSGRYRASVESILIFNSMNQLNS
LLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDA
IETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALHPL
PGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRIT
FTEPNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLELRI
LAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYG
IIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDG
FVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNI
QKQLETFHSTFKSHGHRECPIRGGFFILQLHDELLYEVAEEDVVQVAQIV
KNEMESAVKLSVKLKVKVKIGASWGELKDFDV
3D structure
PDB7zx0 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
ChainEEE
Resolution2.99 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7zx0, PDBe:7zx0, PDBj:7zx0
PDBsum7zx0
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

[Back to BioLiP]