Structure of PDB 7z4o Chain EEE

Receptor sequence
>7z4oEEE (length=615) Species: 11320 (Influenza A virus) [Search protein sequence]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEELNKRSYLIRALTLNTMTKDAER
GKLKRRAIATPGMQIRGFVYFVEALARSICEKLEQSGLPVGGNEKKAKLA
NVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWF
RNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQVPAEMLANIDLKYFNK
STREKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTK
TTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSY
INRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSVGVTVIKNN
MINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRAFELKKLWEQT
RSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPMNPFVS
HYDAVATTHSWIPKR
3D structure
PDB7z4o Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
ChainEEE
Resolution3.412 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna EEE H32 G33 T34 Y38 M356 R365 H32 G33 T34 Y38 M323 R332
BS02 MG EEE G304 D305 D446 E491 G271 D272 D413 E458
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z4o, PDBe:7z4o, PDBj:7z4o
PDBsum7z4o
PubMed35605026
UniProtA0A024E3M6

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