Structure of PDB 7q5w Chain EEE

Receptor sequence
>7q5wEEE (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHG
RKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFN
RPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLI
ATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLL
HEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVP
CQKI
3D structure
PDB7q5w The tandem SH2 domains of SYK
ChainEEE
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide EEE R22 R42 H63 Y64 T65 G98 L99 R175 R195 R197 H215 Y216 I228 E230 G231 K232 K247 D249 G250 L252 R14 R34 H55 Y56 T57 G90 L91 R167 R187 R189 H207 Y208 I220 E222 G223 K224 K239 D241 G242 L244
BS02 peptide EEE D219 K222 D211 K214
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5w, PDBe:7q5w, PDBj:7q5w
PDBsum7q5w
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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