Structure of PDB 7q5u Chain EEE

Receptor sequence
>7q5uEEE (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
SMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALS
VAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLK
KPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQL
EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYA
LCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRV
LTVPCQK
3D structure
PDB7q5u The tandem SH2 domains of SYK
ChainEEE
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide EEE R22 R42 H63 Y64 T65 G98 R175 R195 R197 H215 Y216 G231 K232 K247 D249 G250 R18 R38 H59 Y60 T61 G94 R171 R191 R193 H211 Y212 G227 K228 K243 D245 G246
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5u, PDBe:7q5u, PDBj:7q5u
PDBsum7q5u
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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