Structure of PDB 8scb Chain EE

Receptor sequence

>8scbEE (length=259) Species: 9986 (Oryctolagus cuniculus)

ARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNR
LKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRL
IYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPD
PLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERH
PGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEE
RDKRLAAKQ

3D structure

• PDB: 8scb Structure and consequences of eRF1 glued to the ribosomal decoding center
• Chain: EE
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	EE	A2 R3 G4 P5 K6 K7 H8 K10 V12 K16 M19 D21 K22 T24 F27 P29 R30 T33 G34 P35 K37 L38 R49 T57 G58 K62 M66 R77 K106 R108 K128 F130 V131 G132 K134 G135 V140 A144 T146 R148 K155 G186 H201 P202 G203 A219 R221 R240	A1 R2 G3 P4 K5 K6 H7 K9 V11 K15 M18 D20 K21 T23 F26 P28 R29 T32 G33 P34 K36 L37 R48 T56 G57 K61 M65 R76 K105 R107 K127 F129 V130 G131 K133 G134 V139 A143 T145 R147 K154 G185 H200 P201 G202 A218 R220 R239
BS02	MG	EE	R30 T81	R29 T80

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8scb, PDBe:8scb, PDBj:8scb
• PDBsum: 8scb
• PubMed: 38172604
• UniProt: G1TK17|RS4X_RABIT Small ribosomal subunit protein eS4 (Gene Name=RPS4X)