Structure of PDB 8gxq Chain EA

Receptor sequence
>8gxqEA (length=187) Species: 9606 (Homo sapiens) [Search protein sequence]
VPAALKRLAKYVIRGFYGIEHALALDILIRNSCVKEEDMLELLKFDRKQL
RSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDH
MRRRIETDERDSTNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCHT
EVEEDESAMPKKDARTLLARFNEQIEPIYALLRETED
3D structure
PDB8gxq Structures of +1 nucleosome-bound PIC-Mediator complex.
ChainEA
Resolution5.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN EA C129 C132 C154 C157 C120 C123 C145 C148
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005673 transcription factor TFIIE complex
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:8gxq, PDBe:8gxq, PDBj:8gxq
PDBsum8gxq
PubMed36201575
UniProtP29083|T2EA_HUMAN General transcription factor IIE subunit 1 (Gene Name=GTF2E1)

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