Structure of PDB 6yxy Chain EA

Receptor sequence

>6yxyEA (length=532) Species: 5702 (Trypanosoma brucei brucei)

SFNLPRERQILGGLHADWRTQMKRSGSILNDITPALPDTKRTEEQRRRVA
GWRPVVKLLGDQRLRIAIVGRMNSGKSSLFNLLRLEPTVPGRSNVVRDFD
GITRDSVEGQAQLEGMHFTIIDTPGMVQGRMVEEAFRTVETADAAIFVTA
VDEDIMPEELSLMQYLHLKHMPVVLLANKMDLIQEEEEEAVLDRYNSLGF
GNAIPFSARRKSGLEMLAAVLEPLYHIHAMHKVENDWDIEDLAMQGDESA
MEEIRERNCSDRFIRIAIVGRTNSGKSSLVNRLVGFERNRAVDEKNSTRD
PVELPCSYKGRKLKLIDTAGLARHRYRADRDFIGRIHGLSVNEIRFAHVV
IVVFDATEGHPNKYDMAVLHSVAAEGRPFLLCANKWDAVLDQSATAEAID
FKIKRQVREVKYSNAVVVSAHTGLNLTLLMDQALELYDKWNKRVRRAELT
RLWRKMEKSVIIPYHVARIGRITQVNTRPPTFLLQLQTKNDSNTLPKALQ
EMMKNTLVEEFDFRGVPIRLIQEVKDSNPDYI

3D structure

• PDB: 6yxy Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.
• Chain: EA
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	EA	R68 S69 G70 S71 P134 R367 H368 R369 Y370 R389 N406 K407 A411 H414 R452 R490 R498 R512 R515 V519 K541 Y575 I576	R24 S25 G26 S27 P90 R323 H324 R325 Y326 R345 N362 K363 A367 H370 R408 R446 R454 R468 R471 V475 K497 Y531 I532
BS02	GTP	EA	N117 G119 K120 S121 S122 V140 R141 D142 G145 I146 T147 K223 D225 S251 A252 R253	N73 G75 K76 S77 S78 V96 R97 D98 G101 I102 T103 K179 D181 S207 A208 R209
BS03	MG	EA	S121 T147	S77 T103
BS04	GTP	EA	N317 S318 G319 K320 S321 S322 V336 D337 N340 S341 T342 G364 K429 D431 A464 H465	N273 S274 G275 K276 S277 S278 V292 D293 N296 S297 T298 G320 K385 D387 A420 H421
BS05	MG	EA	S321 T342	S277 T298

Gene Ontology

Molecular Function

• GO:0005525 GTP binding

External links

• PDB: RCSB:6yxy, PDBe:6yxy, PDBj:6yxy
• PDBsum: 6yxy
• PubMed: 32679035
• UniProt: Q57TZ4