Structure of PDB 7ls1 Chain E1

Receptor sequence

>7ls1E1 (length=174) Species: 10090 (Mus musculus) [Search protein sequence]

QDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSK
ARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDT
GNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIG
AKHRISKEEAMRWFQQKYDGIILP

3D structure

PDB

7ls1 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	E1	K19 C21 N23 C25 S51 A53 F60 I62 A69 N97 N98 S100 D101 T102 N104 G106 F107 G127 D129 Y131 V133 K145	K17 C19 N21 C23 S49 A51 F58 I60 A67 N95 N96 S98 D99 T100 N102 G104 F105 G125 D127 Y129 V131 K143
BS02	rna	E1	E9 M12 R16 T47 V49 T73 R75 P137 S140 I141 D143 K144 R147 C150 I151 A153 K154 H155 R156	E7 M10 R14 T45 V47 T71 R73 P135 S138 I139 D141 K142 R145 C148 I149 A151 K152 H153 R154

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006605	protein targeting
GO:0010628	positive regulation of gene expression
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0042273	ribosomal large subunit biogenesis
GO:0050821	protein stabilization
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1901798	positive regulation of signal transduction by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7ls1, PDBe:7ls1, PDBj:7ls1
PDBsum	7ls1
PubMed	34815424
UniProt	Q9CXW4\|RL11_MOUSE Large ribosomal subunit protein uL5 (Gene Name=Rpl11)

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