Structure of PDB 6yxx Chain E1

Receptor sequence

>6yxxE1 (length=473) Species: 5702 (Trypanosoma brucei brucei)

SFKRLPFGRRSTSGGVNFNKGLLTDRERGDPFTEPHAYRNKKSIAAISKV
AKKQDILLREEKQRKELDKIQSGYVTERELHIGCDKPLGGNANEIARVID
EQALISPTPGEKCSTALRELMENEVDRRNHMMDKFGQPVGAREFHRLFKE
LRHADNEAETIERHQTRLVEEYGVYPSLRLDAYMLDDDTYFPEWVNALPY
SIRDRVKFGSLGLTEKDEALRVTLGRMPLDRRRREWERLKKAKEYKAAKE
ETLTLAELRDARQGKRRFHWLQRKRQKRASILRRLALRKPDAFELWPSRV
VDYSQRIAFIAQHVENGLDTKGQWPLDPEELARARVRRSKEEAERTFLMS
AEEKRAHKKLSGRSGDGSISEMLQSLEVPDKPFKRLSRKVYANRVNAIVH
GDQDEYGRRYRKMETRSKRRMRPYASLGEIGLENELRKEPRINAKGLNNT
DDEDWPRHTKSWGDGMPSMRYGS

3D structure

• PDB: 6yxx Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.
• Chain: E1
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	E1	S10 F11 K12 R13 L14 P15 F16 R19 S20 G23 H45 N49 K51 V134 D135 R136 R137 H139 M140 K143 A150 F153 H154 F157 K158 H162 N165 A206 L207 P208 Y209 S210 R271 Q272 R297 K298 D300 A301 F302 R372 K393 R394 S396 R397 K398 V399 Y400 A401 R403 N405 H409 D411 R417 R418 R420 K421 E423 R425 R428 R450 L456 N457 R466 K469 W471 G472 S477 R479 Y480	S1 F2 K3 R4 L5 P6 F7 R10 S11 G14 H36 N40 K42 V125 D126 R127 R128 H130 M131 K134 A141 F144 H145 F148 K149 H153 N156 A197 L198 P199 Y200 S201 R262 Q263 R288 K289 D291 A292 F293 R363 K384 R385 S387 R388 K389 V390 Y391 A392 R394 N396 H400 D402 R408 R409 R411 K412 E414 R416 R419 R441 L447 N448 R457 K460 W462 G463 S468 R470 Y471

Gene Ontology

Cellular Component

• GO:0005739 mitochondrion
• GO:0005762 mitochondrial large ribosomal subunit

External links

• PDB: RCSB:6yxx, PDBe:6yxx, PDBj:6yxx
• PDBsum: 6yxx
• PubMed: 32679035
• UniProt: Q57WG6