Structure of PDB 9f42 Chain E

Receptor sequence

>9f42E (length=1052) Species: 9606 (Homo sapiens)

EADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLN
VGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRA
RYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVF
NKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQEL
EVSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKC
VSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLF
QKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWD
LAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQL
PIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSS
ARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRT
MTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGR
IWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAER
TDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVAL
QFISVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKFISATVQTGFCD
WSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGIT
RLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFH
NGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTA
WQGLSAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCV
TSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASL
QKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIA
CGSVNQFTAIYNSSGELINNIKYAISCLAFHPHWPHLAVGSNDYYISVYS
VE

3D structure

• PDB: 9f42 mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR
• Chain: E
• Resolution: 3.27 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	E	R305 D321 R338 L437 Q438 L440 L441 Q443 R446 P474 Y475 K478 L479 Q481 S482 S483	R272 D288 R305 L404 Q405 L407 L408 Q410 R413 P441 Y442 K445 L446 Q448 S449 S450

External links

• PDB: RCSB:9f42, PDBe:9f42, PDBj:9f42
• PDBsum: 9f42
• PubMed: 39141345
• UniProt: Q8N122|RPTOR_HUMAN Regulatory-associated protein of mTOR (Gene Name=RPTOR)