Structure of PDB 9bs3 Chain E

Receptor sequence

>9bs3E (length=487) Species: 9606 (Homo sapiens) [Search protein sequence]

LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRD
IARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVL
AALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEV
PDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEE
AAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKL
PSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEF
LEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKK

3D structure

PDB

9bs3 Structures of LIG1 uncover the mechanism of sugar discrimination against 5'-RNA-DNA junctions during ribonucleotide excision repair.

Chain

Resolution

2.69 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	E	G348 G350 G571 Q572 S588 R589 E592 F635	G88 G90 G311 Q312 S328 R329 E332 F375
BS02	dna	E	R589 R738 K744	R329 R478 K484
BS03	dna	E	R305 T415 G416 A418 T420 R451 G453 A455 Q457 S458 R557 Q636 T639 T640 K642 R643 H740	R45 T155 G156 A158 T160 R191 G193 A195 Q197 S198 R297 Q376 T379 T380 K382 R383 H480
BS04	AMP	E	K568 Y569 E621 F660 E720 M723 K725 K744 K746	K308 Y309 E361 F400 E460 M463 K465 K484 K486

External links

PDB	RCSB:9bs3, PDBe:9bs3, PDBj:9bs3
PDBsum	9bs3
PubMed	39159820
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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