Structure of PDB 9b3r Chain E

Receptor sequence
>9b3rE (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]
ETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSY
VGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPT
LLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVL
DSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTT
AEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNE
RFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGT
TMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQ
QMWISKQEYDEAGPSIVHRKCF
3D structure
PDB9b3r Structure of human cardiac actin
ChainE
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E G13 L16 K213 E214 G302 Y306 K336 G10 L13 K210 E211 G299 Y303 K333
Gene Ontology
Molecular Function
GO:0000146 microfilament motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017022 myosin binding
Biological Process
GO:0007015 actin filament organization
GO:0010628 positive regulation of gene expression
GO:0030048 actin filament-based movement
GO:0030240 skeletal muscle thin filament assembly
GO:0031032 actomyosin structure organization
GO:0033275 actin-myosin filament sliding
GO:0043066 negative regulation of apoptotic process
GO:0055003 cardiac myofibril assembly
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060047 heart contraction
GO:0070252 actin-mediated cell contraction
GO:0090131 mesenchyme migration
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030017 sarcomere
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0031674 I band
GO:0044297 cell body
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:9b3r, PDBe:9b3r, PDBj:9b3r
PDBsum9b3r
PubMed
UniProtP68032|ACTC_HUMAN Actin, alpha cardiac muscle 1 (Gene Name=ACTC1)

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