Structure of PDB 8x6r Chain E

Receptor sequence
>8x6rE (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQERDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKD
SEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDA
FYTLVREIRKHKEK
3D structure
PDB8x6r Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors.
ChainE
Resolution1.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP E G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 G13 V14 G15 K16 S17 A18 F28 D30 N111 K112 D114 L115 S140 A141
BS02 Y9D E C12 K16 A59 E62 R68 D69 M72 H95 Y96 Q99 C12 K16 A59 E62 R63 D64 M67 H90 Y91 Q94
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8x6r, PDBe:8x6r, PDBj:8x6r
PDBsum8x6r
PubMed38176113
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

[Back to BioLiP]