Structure of PDB 8x6f Chain E

Receptor sequence

>8x6fE (length=271) Species: 1280 (Staphylococcus aureus) [Search protein sequence]

DPVRMYLKEIGRVNLLSAQEEIELAKRIEQGDEVAKSRLAEANLRLVVSI
AKRYVGRGMLFLDLIQEGNMGLIKAVEKFDFNKGFKFSTYATWWIRQAIT
RAIADQARTIRIPVHMVETINKLIRVQRQLLQDLGRDPAPEEIGEEMDLP
AEKVREVLKIAQEPVSLETPIGEEDDSHLGDFIEDQEAQSPSDHAAYELL
KEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEEVGKVFGVTRERIRQI
EAKALRKLRHPSRSKRLKDFM

3D structure

PDB

8x6f Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase

Chain

Resolution

3.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	E	R100 L103 L111 N139 R141 L142 S145 K148 K174 K179 F181 K182 S184 T185 Y186 T188 W189 Q193 P209 H211 R342 Q345	R4 L7 L15 N43 R45 L46 S49 K52 K78 K83 F85 K86 S88 T89 Y90 T92 W93 Q97 P113 H115 R246 Q249
BS02	dna	E	R153 Q193 R318 T328 L329 R340 E341	R57 Q97 R222 T232 L233 R244 E245

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0016987	sigma factor activity

	Biological Process
GO:0006352	DNA-templated transcription initiation
GO:0006355	regulation of DNA-templated transcription
GO:0010468	regulation of gene expression
GO:2000142	regulation of DNA-templated transcription initiation

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8x6f, PDBe:8x6f, PDBj:8x6f
PDBsum	8x6f
PubMed	38844782
UniProt	P0A0J0\|SIGA_STAA8 RNA polymerase sigma factor SigA (Gene Name=sigA)

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