Structure of PDB 8wus Chain E

Receptor sequence

>8wusE (length=453) Species: 11801 (Moloney murine leukemia virus) [Search protein sequence]

TWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLG
IKPHIQRLLDQGILVPCQSPWNTPLLPVKKPGTNDYRPVQDLREVNKRVE
DIHPTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQPLFAFEWR
DPEMGISGQLTWTRLPQGFKNSPTLFNEALHRDLADFRIQHPDLILLQYV
DDLLLAATSELDCQQGTRALLQTLGNLGYRASAKKAQICQKQVKYLGYLL
KEGQRWLTEARKETVMGQPTPKTPRQLREFLGKAGFCRLFIPGFAEMAAP
LYPLTKPGTLFNWGPDQQKAYQEIKQALLTAPALGLPDLTKPFELFVDEK
QGYAKGVLTQKLGPWRRPVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDA
GKLTMGQPLVILAPHAVEALVKQPPARMTHYQALLLDTDRVQFGPVVALN
PAT

3D structure

PDB

8wus Structural basis for pegRNA-guided reverse transcription by a prime editor.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	E	Y64 L99 V101 V112 D114 R116 V129 N131 Y133 G191 F192 K193 P196 R311 Y325 K329 K397 K425	Y41 L76 V78 V89 D91 R93 V106 N108 Y110 G168 F169 K170 P173 R288 Y302 K306 K374 K402
BS02	dna	E	R110 F155 Q190 Y222 D224 R284 R298 R301 E302 G305 V402	R87 F132 Q167 Y199 D201 R261 R275 R278 E279 G282 V379

External links

PDB	RCSB:8wus, PDBe:8wus, PDBj:8wus
PDBsum	8wus
PubMed	38811740
UniProt	Q8UN00

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